Emapticap pegol (NOX-E36) is a Spiegelmer that binds and inhibits the chemokine CCL2 (MCP-1).
Haller concludes: "The inhibition of the CCL2:CCR2 axis with emapticap pegol is well tolerated and reduces ACR and HbA1c in type 2 diabetics with albuminuria.
Emapticap pegol was generally safe and well tolerated in this study.Rugby Union noun no pl, soviet Union noun no pl hist student union, students' union noun, are you missing a word, phrase examens concours clermont ferrand or translation?English » German, u unio, union, union ju:njn noun.The exploratory trial was laid out as a randomized, double blind, placebo-controlled phase IIa study and enrolled 75 albuminuric type 2 diabetics on a stable standard of care regimen which mandatorily included RAS* blockade.Lexaptepid pegol (NOX-H94 an anti-hepcidin Spiegelmer, has completed a Phase IIa pilot study in cancer patients with anemia and will soon begin a study in EPO-hyporesponsive dialysis patients.
HbA1c d85 (end of therapy hbA1c d113 (peak effect: 1 month off therapy) change p-value change p-value change p-value change p-value, iTT dataset.221 -26.064 -4.146 -6.026.The Spiegelmer platform provides the company with powerful and unique cfj concours 2018 code promo prime energie leclerc 2016 discovery capabilities, which have generated a number of additional leads under preclinical investigation.Peas dataset.014 -39.010 -5.096 -7.036, importantly, the effect on ACR was not accompanied by relevant hemodynamic changes which is consistent with a novel mechanism of action and differentiates emapticap pegol from approved drugs.CCL2 is a pro-inflammatory chemokine involved in the recruitment of immune cells to inflamed tissues.Emapticap was administered subcutaneously.5 mg/kg twice weekly for 12 weeks, followed by a treatment-free observation phase of 12 weeks.Submit a new entry.The maintenance of the effects even after cessation of treatment suggests that CCL2 blockade interferes with the underlying pathophysiology.In the Full Analysis Set/ Intent to Treat (ITT) population, strong trends were seen for reduction of protein in the urine as measured by the albumin to creatinine ratio (ACR as well as for glycated hemoglobin (HbA1c) in blood.Berlin (pta010/10:30) -, full clinical data presentation for anti-CCL2 /MCP-1 Spiegelmer emapticap pegol (NOX-E36).
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Olaptesed pegol (NOX-A12 an anti-cxcl12/SDF-1 (CXC chemokine ligand 12 / Stromal Cell-Derived Factor-1) Spiegelmer, is currently in Phase IIa studies in two hematological cancers, multiple myeloma (MM) and chronic lymphocytic leukemia (CLL).
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Located in Berlin, Germany, noxxon is a well-financed mature biotech company with a strong syndicate of international investors, and approximately 60 employees.